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Animal products are a particularly potent source especially red meat

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Diphthamide biosynthesis genes are essential to normal development, and deletion of these genes in mice leads to developmental defects including embryonic lethality, while mutations found in humans are associated with developmental delays, intellectual disability, craniofacial and genital abnormalities (Nakajima et al, 2018)

Conclusion: direct IV NAD+ has a real biological effect , although the mechanism is more complex than simple replenishment of the NAD+ pool (via metabolites)

In addition, more clinical trials are required to validate the clinical utility of ferroptosis biomarkers such as MDA and GSH in early diagnosis and treatment decisions for CKD-related retinal lesions, improving the clinical translational potential of these findings